Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.50 |
| ▸ | JAK1 | P23458 | 7/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL101288 | 0.88 | JAK2 (0.61) | JAK2HDAC6JAK1HDAC1JAK3 | |
| SCHEMBL15399202 | 0.86 | JAK2 (0.63) | JAK2HDAC6JAK1HDAC1JAK3 | |
| Trifluoroacetic Acid SCHEMBL5134407 | 0.83 | AURKB (0.57) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL15389391 | 0.82 | JAK2 (0.60) | JAK2HDAC6JAK1HDAC1JAK3 | |
| SCHEMBL103973 | 0.81 | JAK2 (0.61) | JAK2HDAC6JAK1HDAC1JAK3 | |
| Trifluoroacetic Acid SCHEMBL4082191 | 0.80 | JAK2 (0.59) | JAK2HDAC6JAK1HDAC1JAK3 | |
| Trifluoroacetic Acid SCHEMBL860378 | 0.80 | JAK2 (0.54) | JAK2HDAC6JAK1HDAC1JAK3 | |
| SCHEMBL19832101 | 0.80 | JAK2 (1.00) | JAK2HDAC6JAK1HDAC1JAK3 | |
| Trifluoroacetic Acid SCHEMBL98584 | 0.79 | JAK2 (0.65) | JAK2HDAC6JAK1HDAC1JAK3 | |
| Trifluoroacetic Acid SCHEMBL20943722 | 0.79 | JAK2 (0.65) | JAK2HDAC6JAK1HDAC1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9814722-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160346286-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | INCYTE CORPORATION | 2016-12-01 | — | — | US | disclosed |
| US-9206187-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase | INCYTE HOLDINGS CORPORATION (US) | 2015-12-08 | — | — | US | disclosed |
| US-8946245-B2 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORPORATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140005210-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | INCYTE CORPORATION (US) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160346286-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | JAK3, JAK1, JAK2 | JAK2 3/4885HDAC6 2492/4885JAK1 2/4885 |
| US-20140005210-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | JAK3, JAK1, JAK2 | JAK2 3/4885HDAC6 2492/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.