Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 5/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749745 | 0.82 | PIK3CA (0.49) | PIK3CAPRKDCGPR142MTORCYP2D6 | |
| SCHEMBL9288018 | 0.79 | PIK3CA (0.51) | PIK3CAPRKDCMTOR | |
| SCHEMBL856320 | 0.79 | PIK3CA (0.49) | PIK3CAPRKDCGPR142MTOR | |
| SCHEMBL2724620 | 0.79 | PIK3CA (0.41) | PIK3CAPRKDCPIK3CDPIK3CBPIK3CG | |
| SCHEMBL30405764 | 0.79 | PIK3CA (0.62) | PIK3CAPRKDCGPR142MTOR | |
| SCHEMBL3752728 | 0.79 | PIK3CA (0.62) | PIK3CAPRKDCGPR142MTOR | |
| SCHEMBL3756231 | 0.77 | PIK3CA (0.70) | PIK3CAGPR142MTOR | |
| SCHEMBL2724334 | 0.77 | PIK3CA (0.47) | PIK3CAPRKDCGPR142MTOR | |
| SCHEMBL3277263 | 0.76 | PIK3CA (0.60) | PIK3CAGPR142 | |
| SCHEMBL9288017 | 0.75 | PIK3CA (0.45) | PIK3CAPRKDCPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140005172-A1 | Benzoxazepines as Inhibitors of PI3K/M TOR and Methods of Their Use and Manufacture | ELELIXIS, INC. (US) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005172-A1 | Benzoxazepines as Inhibitors of PI3K/M TOR and Methods of Their Use and Manufacture | MTOR, RICTOR, PIK3R2 | PIK3CA 4/4885PRKDC 2472/4885PIK3CD 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.