Terephthalamide

Terephthalamide

SCHEMBL15399897

NC(=O)c1ccc(C(N)=O)cc1.O=C(O)c1c(O)cc[nH]c1=O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 1/20 0.42
PARP10 Q53GL7 4/20 0.40
PARP15 Q460N3 2/20 0.40
POLB P06746 1/20 0.39
CYP3A4 P08684 1/20 0.39
PARP1 P09874 1/20 0.39
MAPT P10636 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
PMP22 Q01453 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CA2 P00918 2/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1232001 0.88 CA12 (0.48) PARP15CYP3A4PARP1MAPTBLM
Hydrochloric Acid SCHEMBL17597734 0.86 CA12 (0.46) PARP15CYP3A4PARP1MAPTBLM
Hydrochloric Acid SCHEMBL17595029 0.86 CA12 (0.46) PARP15CYP3A4PARP1MAPTBLM
SCHEMBL2826027 0.82 DAO (0.43) TYK2PARP15POLBCYP3A4PARP1
SCHEMBL1643442 0.69 DAO (0.42) PARP15CYP3A4PARP1BLMHSD17B10
SCHEMBL26619127 0.69 NAPRT (0.55) PARP15CYP3A4PARP1MAPTBLM
SCHEMBL17029566 0.68 DAO (0.41) PARP15CYP3A4PARP1BLMHSD17B10
SCHEMBL2223763 0.67 NOTUM (0.45) PARP15CYP3A4PARP1BLMHSD17B10
SCHEMBL3653849 0.67 DPP4 (0.47) TYK2HSD17B10TDP1NAPRTALDH1A1
SCHEMBL3648576 0.67 NAPRT (0.44) PARP15CYP3A4PARP1MAPTBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9290535-B2 Uridine-based gadolinium complex and MRI contrast agent including the same Korea University Researchand Business Foundation (KR) 2016-03-22 US disclosed
US-20140005369-A1 URIDINE-BASED GADOLINIUM COMPLEX AND MRI CONTRAST AGENT INCLUDING THE SAME KOREA BASIC SCIENCE INSTITUTE (KR) 2014-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140005369-A1 URIDINE-BASED GADOLINIUM COMPLEX AND MRI CONTRAST AGENT INCLUDING THE SAME HNRNPUL1, UGP2, HNRNPUL2 TYK2 4729/4885PARP10 2506/4885PARP15 2713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.