Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | WHR1 | P49842 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589865 | 0.95 | MAPT (0.41) | MAPTMEN1KMT2ASMN1; SMN2SCN9A | |
| SCHEMBL588838 | 0.88 | MEN1 (0.42) | MAPTMEN1KMT2ASMN1; SMN2SCN9A | |
| Trifluoroacetic Acid SCHEMBL17019867 | 0.84 | WHR1 (0.36) | SCN9AWHR1HTR2CHTR2ASLC2A1 | |
| Trifluoroacetic Acid SCHEMBL591049 | 0.84 | JAK2 (0.41) | SCN9ABTKSLC2A1 | |
| SCHEMBL591054 | 0.82 | TRPV1 (0.41) | MAPTMEN1KMT2ASMN1; SMN2SCN9A | |
| SCHEMBL589249 | 0.82 | CCNT1 (0.41) | MAPTMEN1KMT2ASMN1; SMN2POLB | |
| Trifluoroacetic Acid SCHEMBL17019873 | 0.82 | WHR1 (0.35) | MEN1KMT2ASCN9APOLBWHR1 | |
| SCHEMBL588906 | 0.81 | HTR2C (0.41) | MAPTMEN1KMT2ASMN1; SMN2SCN9A | |
| Trifluoroacetic Acid SCHEMBL589894 | 0.81 | C1S (0.42) | MAPTMEN1KMT2ASMN1; SMN2SCN9A | |
| Trifluoroacetic Acid SCHEMBL17019876 | 0.81 | TRPV1 (0.37) | MEN1KMT2ASCN9AWHR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822474-B2 | 6,7-dihydrothieno[3,2-d]pyrimidine for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-02 | — | — | US | disclosed |
| US-20140005154-A1 | 6,7-Dihydrothieno[3,2-d]pyrimidine for the Treatment of Inflammatory Diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140005154-A1 | 6,7-Dihydrothieno[3,2-d]pyrimidine for the Treatment of Inflammatory Diseases | DPYD, TYMS, TPMT | MAPT 2510/4885MEN1 3861/4885KMT2A 4366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.