Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3515104 | 0.84 | DPP4 (0.58) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL2685859 | 0.78 | DPP4 (0.47) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL3514413 | 0.77 | DPP4 (0.41) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL15346013 | 0.77 | DPP4 (0.71) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL15346060 | 0.77 | DPP4 (0.71) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL15346016 | 0.77 | DPP4 (0.71) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL30357985 | 0.77 | DPP4 (0.71) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL3807159 | 0.73 | DPP4 (0.38) | DPP4DPP8DPP7DPP9ACE | |
| SCHEMBL15417122 | 0.68 | DPP4 (0.36) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL28140300 | 0.68 | DPP4 (0.36) | DPP4DPP8DPP7DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8624026-B2 | Method of preparing sitagliptin and intermediates used therein | HANMI SCIENCE CO., LTD (KR) | 2014-01-07 | — | — | US | disclosed |