Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 16/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 14/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413122 | 0.73 | FGFR4 (0.46) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15434031 | 0.72 | FGFR1 (0.67) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413093 | 0.71 | FGFR1 (0.72) | FGFR1FGFR4 | |
| SCHEMBL15434045 | 0.68 | FGFR1 (0.67) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413472 | 0.68 | FGFR4 (0.70) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413223 | 0.68 | FGFR1 (0.61) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL15434027 | 0.68 | FGFR1 (0.54) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL19499705 | 0.68 | FGFR1 (0.56) | FGFR1FGFR4FGFR2FGFR3CSF1R | |
| SCHEMBL19470189 | 0.67 | FGFR1 (0.55) | FGFR1FGFR4FGFR2FGFR3CSF1R | |
| SCHEMBL19499709 | 0.67 | FGFR1 (0.59) | FGFR1FGFR4FGFR2FGFR3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-A2 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | Blueprint Medicines Corporation (US) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014011900-A2 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES (US) | 2014-01-16 | — | — | WO | disclosed |