Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15411071 | 0.86 | GRM5 (0.36) | JAK2IKBKBADORA1ELANEBRD4 | |
| SCHEMBL15411069 | 0.84 | EGLN2 (0.42) | JAK2ELANEMAT2AADORA2AEGLN2 | |
| SCHEMBL15425510 | 0.84 | PDPK1 (0.36) | JAK2IKBKBADORA1ELANEBRD4 | |
| SCHEMBL15410877 | 0.83 | ELANE (0.46) | IKBKBADORA1ELANEBRD4MAT2A | |
| SCHEMBL15411115 | 0.83 | CYP1A2 (0.41) | IKBKBELANEMAT2ACYP1A2CYP3A4 | |
| SCHEMBL15412110 | 0.80 | ELANE (0.38) | ELANEMAT2ACYP3A4CYP2C9 | |
| SCHEMBL15411073 | 0.77 | IKBKB (0.44) | JAK2IKBKBADORA1BRD4CYP1A2 | |
| SCHEMBL15411044 | 0.76 | ELANE (0.37) | ELANECYP2C19KDM4E | |
| SCHEMBL15411727 | 0.76 | ADORA2A (0.39) | ELANEMAT2ACYP3A4CYP2C9ADORA2A | |
| SCHEMBL15412214 | 0.76 | ADORA2A (0.39) | ELANEMAT2AADORA2AEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872509-B1 | INHIBITION OF ENZYMES | CHIESI FARMA SPA (IT) | 2016-09-14 | — | — | EP | disclosed |
| EP-2872509-A1 | INHIBITION OF ENZYMES | Chiesi Farmaceutici S.p.A. (IT) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009425-A1 | INHIBITION OF ENZYMES | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-01-16 | — | — | WO | disclosed |