Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.72 |
| ▸ | JAK3 | P52333 | 14/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.72 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228110 | 0.90 | JAK2 (0.77) | JAK2JAK3PTK2 | |
| SCHEMBL3230482 | 0.88 | JAK2 (0.68) | JAK2JAK3PTK2 | |
| SCHEMBL12090232 | 0.85 | JAK2 (0.65) | JAK2JAK3PTK2PSEN1PSEN2 | |
| SCHEMBL13577856 | 0.85 | JAK2 (0.65) | JAK2JAK3PTK2 | |
| SCHEMBL2634460 | 0.84 | JAK2 (1.00) | JAK2JAK3PTK2 | |
| SCHEMBL2640390 | 0.79 | JAK2 (1.00) | JAK2JAK3PTK2PSEN1PSEN2 | |
| SCHEMBL2640500 | 0.79 | JAK2 (0.69) | JAK2JAK3PTK2PSEN1PSEN2 | |
| SCHEMBL3769359 | 0.79 | JAK2 (1.00) | JAK2JAK3PTK2 | |
| SCHEMBL3227238 | 0.79 | JAK2 (0.70) | JAK2JAK3PTK2 | |
| SCHEMBL20773 | 0.76 | JAK2 (0.53) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633173-B2 | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives | CEPHALON, INC (US) | 2014-01-21 | — | — | US | disclosed |