Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31645550 | 0.89 | AXL (0.43) | MKNK1MKNK2AXLLRRK2MAP4K4 | |
| SCHEMBL15415744 | 0.84 | IRAK1 (0.55) | IRAK1 | |
| SCHEMBL967870 | 0.83 | KCNH2 (0.54) | MKNK1MKNK2ACVR1AXLLRRK2 | |
| SCHEMBL15416785 | 0.79 | BRD4 (0.47) | AXLLRRK2IRAK1 | |
| SCHEMBL15747733 | 0.74 | CYP11B1 (0.49) | AXLKDRCHEK1FGFR3MAPT | |
| SCHEMBL844281 | 0.74 | LRRK2 (0.61) | MKNK1MKNK2ACVR1NPC1RAB9A | |
| SCHEMBL28432597 | 0.74 | MKNK1 (0.49) | MKNK1MKNK2ACVR1AXLLRRK2 | |
| SCHEMBL15747734 | 0.73 | FYN (0.47) | AXLLRRK2KDRCHEK1FGFR3 | |
| SCHEMBL16222829 | 0.72 | NPC1 (0.65) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL16712024 | 0.72 | FYN (0.55) | MKNK1MKNK2ACVR1LRRK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872501-A1 | PYRIMIDINE PYRAZOLYL DERIVATIVES | Ares Trading S.A. (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014008992-A1 | PYRIMIDINE PYRAZOLYL DERIVATIVES | ARES TRADING S.A. (CH) | 2014-01-16 | — | — | WO | disclosed |