Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15418754 | 1.00 | BACE1 (0.76) | BACE1KCNH2CTSD | |
| SCHEMBL15418686 | 0.88 | BACE1 (0.65) | BACE1KCNH2CTSD | |
| SCHEMBL15418851 | 0.88 | BACE1 (0.65) | BACE1KCNH2CTSD | |
| SCHEMBL15418605 | 0.88 | BACE1 (0.87) | BACE1KCNH2CTSD | |
| SCHEMBL2521726 | 0.87 | BACE1 (0.75) | BACE1KCNH2CTSD | |
| SCHEMBL2521722 | 0.87 | BACE1 (0.75) | BACE1KCNH2CTSD | |
| SCHEMBL15418731 | 0.87 | BACE1 (0.75) | BACE1KCNH2CTSD | |
| SCHEMBL2019867 | 0.87 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL15418730 | 0.86 | BACE1 (0.82) | BACE1KCNH2CTSD | |
| SCHEMBL15418857 | 0.86 | BACE1 (0.82) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-B1 | AMINO-DIHYDROOXAZINE AND AMINO-DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA-SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC (US) | 2014-01-22 | — | — | EP | disclosed |