Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15418807 | 1.00 | BACE1 (0.46) | BACE1KCNH2 | |
| SCHEMBL2519887 | 0.89 | BACE1 (0.47) | BACE1KCNH2 | |
| SCHEMBL2519888 | 0.89 | BACE1 (0.47) | BACE1KCNH2 | |
| SCHEMBL2522202 | 0.89 | BACE1 (0.43) | BACE1KCNH2 | |
| SCHEMBL2522203 | 0.89 | BACE1 (0.43) | BACE1KCNH2 | |
| SCHEMBL2524126 | 0.84 | BACE1 (0.36) | BACE1 | |
| SCHEMBL2524125 | 0.84 | BACE1 (0.36) | BACE1 | |
| SCHEMBL2522536 | 0.81 | BACE1 (0.58) | BACE1KCNH2 | |
| SCHEMBL2522533 | 0.81 | BACE1 (0.58) | BACE1KCNH2 | |
| SCHEMBL15134932 | 0.80 | BACE1 (0.34) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012446-B2 | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |
| EP-2547686-B1 | AMINO-DIHYDROOXAZINE AND AMINO-DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA-SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC (US) | 2014-01-22 | — | — | EP | disclosed |