Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.48 |
| ▸ | CTSD | P07339 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15418908 | 1.00 | BACE1 (0.48) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2371429 | 0.90 | BACE1 (0.46) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2371419 | 0.90 | BACE1 (0.46) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2521694 | 0.88 | BACE1 (0.49) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2521696 | 0.88 | BACE1 (0.49) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL2521701 | 0.79 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL2521708 | 0.79 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL2524125 | 0.78 | BACE1 (0.36) | BACE1 | |
| SCHEMBL2524126 | 0.78 | BACE1 (0.36) | BACE1 | |
| SCHEMBL11894446 | 0.77 | BACE1 (0.44) | BACE1CTSDKCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012446-B2 | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2015-04-21 | — | — | US | disclosed |
| EP-2547686-B1 | AMINO-DIHYDROOXAZINE AND AMINO-DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA-SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC (US) | 2014-01-22 | — | — | EP | disclosed |