Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.87 |
| ▸ | CTSD | P07339 | 2/20 | 0.71 |
| ▸ | CTSE | P14091 | 1/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520476 | 1.00 | BACE1 (0.87) | BACE1CTSDCTSEBACE2KCNH2 | |
| SCHEMBL2520477 | 1.00 | BACE1 (0.87) | BACE1CTSDCTSEBACE2KCNH2 | |
| SCHEMBL2372562 | 0.93 | BACE1 (1.00) | BACE1CTSDCTSEBACE2KCNH2 | |
| SCHEMBL2372574 | 0.93 | BACE1 (1.00) | BACE1CTSDCTSEBACE2KCNH2 | |
| SCHEMBL2522476 | 0.90 | BACE1 (0.87) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL2524129 | 0.90 | BACE1 (0.87) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL15418849 | 0.90 | BACE1 (0.87) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL15418751 | 0.88 | BACE1 (0.87) | BACE1CTSDCTSEBACE2KCNH2 | |
| SCHEMBL2519262 | 0.88 | BACE1 (0.74) | BACE1CTSDCTSEBACE2KCNH2 | |
| SCHEMBL2519268 | 0.88 | BACE1 (0.74) | BACE1CTSDCTSEBACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-B1 | AMINO-DIHYDROOXAZINE AND AMINO-DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA-SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC (US) | 2014-01-22 | — | — | EP | disclosed |