Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1530745 | 0.95 | CRBN (0.66) | CRBNCYP3A4BRD4NR3C1AR | |
| SCHEMBL1530701 | 0.90 | CRBN (0.64) | CRBNCYP3A4CYP17A1BRD4 | |
| SCHEMBL1530321 | 0.89 | CRBN (0.63) | CRBNCYP3A4SLC22A12BRD4 | |
| SCHEMBL1531039 | 0.89 | CRBN (0.63) | CRBNCYP3A4BRD4 | |
| SCHEMBL478823 | 0.88 | CRBN (0.63) | CRBNCYP3A4BRD4 | |
| SCHEMBL1530470 | 0.87 | CRBN (0.52) | CRBN | |
| SCHEMBL1530897 | 0.87 | CRBN (0.60) | CRBNCYP3A4 | |
| SCHEMBL1530227 | 0.85 | CRBN (0.59) | CRBNCYP3A4 | |
| SCHEMBL1530679 | 0.84 | CRBN (0.59) | CRBNCYP3A4CYP17A1BRD4 | |
| SCHEMBL1530851 | 0.82 | CRBN (0.54) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-B1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBVIE BAHAMAS LTD (BS) | 2014-01-22 | — | — | EP | claimed |