Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.78 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.78 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.78 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.78 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3424056 | 0.88 | EGLN1 (0.86) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3422096 | 0.88 | EGLN1 (1.00) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3422098 | 0.88 | EGLN1 (1.00) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3421361 | 0.88 | EGLN1 (1.00) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3423522 | 0.88 | EGLN1 (1.00) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3419112 | 0.88 | EGLN1 (1.00) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3423425 | 0.87 | EGLN1 (0.97) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3419140 | 0.87 | EGLN1 (0.97) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| Bicarbonate SCHEMBL15419071 | 0.87 | EGLN1 (0.97) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 | |
| SCHEMBL3421189 | 0.87 | EGLN1 (0.97) | EGLN1EGLN2HIF1ANEGLN3OGFOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037922-B9 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-08-23 | — | — | EP | claimed |
| EP-2037922-B1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-22 | — | — | EP | claimed |