Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.66 |
| ▸ | IL17A | Q16552 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30434520 | 0.89 | BRD4 (0.73) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL146190 | 0.89 | BRD4 (0.73) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL26241241 | 0.85 | BRD4 (0.68) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL147943 | 0.83 | BRD4 (0.69) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL348541 | 0.83 | BRD4 (0.66) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL30054393 | 0.83 | BRD4 (0.69) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL15553157 | 0.83 | BRD4 (0.69) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL27851658 | 0.83 | BRD4 (0.78) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| SCHEMBL348295 | 0.82 | BRD4 (0.70) | BRD4IL17AHDAC1HDAC3HDAC4 | |
| Apabetalone SCHEMBL145019 | 0.82 | BRD4 (0.84) | BRD4IL17AHDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118074-B1 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP (CA) | 2014-01-22 | — | — | EP | claimed |