Sugi Predict

Sugi Predict / Compounds / SCHEMBL15420392

SCHEMBL15420392

SCHEMBL15420392

CCOC(=O)c1ccc(OC[C@H]2CC(F)(F)CC[C@@H]2NS(=O)(=O)CC)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.42
▸ STS P08842 1/20 0.40
▸ EPHX2 P34913 1/20 0.39
▸ RARA P10276 2/20 0.39
▸ RARB P10826 2/20 0.39
▸ RAB9A P51151 1/20 0.38
▸ MAPT P10636 2/20 0.38
▸ RECQL P46063 1/20 0.37
▸ GAA P10253 3/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ MMP13 P45452 1/20 0.37
▸ ADRB2 P07550 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ CA1 P00915 2/20 0.37
▸ CA2 P00918 2/20 0.37
▸ CA12 O43570 1/20 0.37
▸ CA9 Q16790 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15420665 0.85 HRH3 (0.40) RAB9AMAPTALDH1A1L3MBTL1
SCHEMBL12987582 0.83 HPGD (0.48) HPGDRAB9AMAPTKMT2ASMN1; SMN2
SCHEMBL12987580 0.83 HPGD (0.48) HPGDRAB9AMAPTKMT2ASMN1; SMN2
SCHEMBL12987326 0.83 KMT2A (0.37) HPGDRAB9AGAAKMT2AALDH1A1
SCHEMBL15440794 0.83 KMT2A (0.37) HPGDRAB9AGAAKMT2AALDH1A1
SCHEMBL12987328 0.83 KMT2A (0.37) HPGDRAB9AGAAKMT2AALDH1A1
SCHEMBL12987358 0.79 IDH1 (0.38) HPGDRAB9AMAPTALDH1A1L3MBTL1
SCHEMBL12987356 0.79 IDH1 (0.38) HPGDRAB9AMAPTALDH1A1L3MBTL1
SCHEMBL15420286 0.79 CXCR1 (0.35) RAB9AMAPTSMN1; SMN2ALDH1A1
SCHEMBL15420288 0.79 CXCR1 (0.35) RAB9AMAPTSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694472-B1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2020-03-11 — — EP disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF GRIN2A, GRIN2B, SLC1A2 HPGD 2650/4885STS 128/4885EPHX2 1496/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.