Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442023 | 0.94 | MELK (0.34) | MELKKAT5MAOBSCN9AP2RX3 | |
| SCHEMBL12989333 | 0.91 | SCN9A (0.35) | MELKKAT5CYP46A1SCN9AP2RX3 | |
| SCHEMBL12988551 | 0.90 | KAT5 (0.34) | MELKKAT5CYP46A1SCN9AP2RX3 | |
| SCHEMBL15420270 | 0.86 | CYP17A1 (0.34) | MELKKAT5CYP46A1CHRM1 | |
| SCHEMBL12989999 | 0.85 | SCN9A (0.35) | MELKKAT5CYP46A1SCN9AP2RX3 | |
| SCHEMBL15420237 | 0.85 | CHRM1 (0.36) | MELKKAT5CYP46A1P2RX3CHRM1 | |
| SCHEMBL15420920 | 0.84 | KAT5 (0.34) | MELKKAT5CYP46A1SCN9AP2RX3 | |
| SCHEMBL15420526 | 0.84 | SCN9A (0.34) | MELKCYP46A1SCN9APRKCQ | |
| SCHEMBL12989671 | 0.84 | KAT5 (0.34) | MELKKAT5CYP46A1SCN9AP2RX3 | |
| SCHEMBL15420299 | 0.83 | MELK (0.33) | MELKKAT5CYP46A1SCN9AP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694472-B1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2020-03-11 | — | — | EP | disclosed |
| US-9527807-B2 | Sulfonamide derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-27 | — | — | US | disclosed |
| US-20140024650-A1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024650-A1 | SULFONAMIDE DERIVATIVE AND USE THEREOF | GRIN2A, GRIN2B, SLC1A2 | MELK 2394/4885KAT5 2329/4885MAOB 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.