Sugi Predict

Sugi Predict / Compounds / SCHEMBL15420497

SCHEMBL15420497

SCHEMBL15420497

CS(=O)(=O)N[C@H]1CCOC[C@@H]1COc1ccc(-c2ccc(C#N)cn2)cc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ HPGD P15428 2/20 0.43
▸ HTT P42858 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ GRIA2 P42262 2/20 0.36
▸ KCNH2 Q12809 1/20 0.36
▸ XDH P47989 1/20 0.36
▸ CCR6 P51684 3/20 0.34
▸ CTSC P53634 1/20 0.34
▸ KDM1A O60341 1/20 0.34
▸ GPR183 P32249 1/20 0.34
▸ GPR119 Q8TDV5 1/20 0.34
▸ APLNR P35414 1/20 0.33
▸ IRAK4 Q9NWZ3 1/20 0.33
▸ EGLN2 Q96KS0 2/20 0.33
▸ EGLN1 Q9GZT9 2/20 0.33
▸ IKBKE Q14164 1/20 0.33
▸ TBK1 Q9UHD2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15420325 0.93 KDM4E (0.46) KDM4EALDH1A1HPGDHTTL3MBTL1
SCHEMBL15420607 0.92 KDM4E (0.45) KDM4EALDH1A1HPGDHTTL3MBTL1
SCHEMBL15420266 0.90 KDM4E (0.41) KDM4EALDH1A1HPGDHTTL3MBTL1
SCHEMBL15441136 0.88 GRIA2 (0.46) GRIA2XDHGPR183GPR119
SCHEMBL12987372 0.88 GRIA2 (0.46) GRIA2XDHGPR183GPR119
SCHEMBL12987282 0.88 GRIA2 (0.38) GRIA2XDHGPR183GPR119
SCHEMBL15420203 0.88 GRIA2 (0.38) GRIA2XDHGPR183GPR119
SCHEMBL15420219 0.85 PPARD (0.41) GRIA2KCNH2XDHCCR6KDM1A
SCHEMBL15441147 0.85 PPARD (0.41) GRIA2KCNH2XDHCCR6KDM1A
SCHEMBL15420171 0.84 KDM4E (0.47) KDM4EALDH1A1HPGDHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694472-B1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2020-03-11 — — EP disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-9527807-B2 Sulfonamide derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-12-27 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-01-23 — — US disclosed
US-20070161771-A1 SYNTHESIS OF ELASTOMERIC CARBORANE-SILOXANES BY HYDROSILATION REACTIONS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2007-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024650-A1 SULFONAMIDE DERIVATIVE AND USE THEREOF GRIN2A, GRIN2B, SLC1A2 KDM4E 2112/4885ALDH1A1 143/4885HPGD 2650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.