Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.44 |
| ▸ | SYK | P43405 | 9/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CD63 | P08962 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176399 | 0.88 | BTK (0.60) | BTK | |
| SCHEMBL1542673 | 0.75 | BTK (0.58) | BTKSYKCD63AURKA | |
| SCHEMBL1542513 | 0.70 | BTK (0.57) | BTK | |
| SCHEMBL1542725 | 0.70 | BTK (0.68) | BTK | |
| SCHEMBL15007448 | 0.66 | BTK (0.54) | BTK | |
| SCHEMBL13531788 | 0.65 | GBA1 (0.41) | SYKCD63AURKA | |
| SCHEMBL3142950 | 0.62 | BTK (0.88) | BTK | |
| SCHEMBL1432900 | 0.62 | BTK (0.89) | BTK | |
| SCHEMBL1432506 | 0.61 | BTK (0.79) | BTK | |
| SCHEMBL13547714 | 0.61 | BTK (0.49) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307418-A1 | NOVEL PHENYLIMIDAZOPYRAZINES | F. Hoffmann-La Roche AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010006970-A1 | NOVEL PHENYLIMIDAZOPYRAZINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-21 | — | — | WO | disclosed |