SCHEMBL15426282

SCHEMBL15426282

CCCn1c(-c2ccccc2S(=O)(=O)CC)nc2cc(C)cnc21

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.41
ALDH1A1 P00352 3/20 0.41
BRD4 O60885 2/20 0.41
LMNA P02545 2/20 0.41
GAA P10253 1/20 0.40
PDE10A Q9Y233 3/20 0.39
AKT1 P31749 2/20 0.37
AKT2 P31751 2/20 0.37
USP1 O94782 1/20 0.37
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.35
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CYP11B1 P15538 1/20 0.34
ATR Q13535 1/20 0.34
RORC P51449 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426280 0.91 BRD4 (0.40) KDM4EALDH1A1BRD4PDE10AAKT1
SCHEMBL15412773 0.88 BRD4 (0.40) KDM4EALDH1A1BRD4PDE10AAKT1
SCHEMBL15412825 0.87 PDE2A (0.41) KDM4EALDH1A1LMNAGAAUSP1
SCHEMBL15426300 0.86 BRD4 (0.40) KDM4EALDH1A1BRD4LMNAPDE10A
SCHEMBL15426297 0.85 BRD4 (0.39) KDM4EBRD4PDE10AAKT1AKT2
SCHEMBL15426289 0.83 FEN1 (0.38) BRD4PDE10AAKT1AKT2USP1
SCHEMBL15426263 0.83 ALOX5AP (0.40) KDM4EALDH1A1BRD4LMNAGAA
SCHEMBL15426288 0.81 CNR2 (0.39) ALDH1A1BRD4PDE10AAKT1AKT2
SCHEMBL15412572 0.78 PDE2A (0.42) LMNAUSP1ALOX5APFEN1KMT2A
SCHEMBL15426279 0.78 BRD4 (0.40) KDM4EALDH1A1BRD4LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 KDM4E 2981/4885ALDH1A1 3178/4885BRD4 1677/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 KDM4E 2968/4885ALDH1A1 3047/4885BRD4 1616/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.