SCHEMBL15426299

SCHEMBL15426299

CCSc1ccccc1-c1nc2cc(C)cnc2n1COC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.39
AKT1 P31749 4/20 0.36
KDM4E B2RXH2 4/20 0.36
HSD17B10 Q99714 3/20 0.36
AKT2 P31751 2/20 0.36
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
NPC1 O15118 4/20 0.34
TP53 P04637 3/20 0.34
RAB9A P51151 3/20 0.34
LMNA P02545 3/20 0.34
MAPT P10636 2/20 0.34
ALDH1A1 P00352 2/20 0.34
TSHR P16473 1/20 0.34
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.34
PDE10A Q9Y233 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
BCHE P06276 1/20 0.33
CDK4 P11802 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426295 0.90 AKT1 (0.38) BRD4AKT1KDM4EHSD17B10AKT2
SCHEMBL15426277 0.88 AKT1 (0.39) BRD4AKT1KDM4EHSD17B10AKT2
SCHEMBL15412430 0.87 POLB (0.41) AKT1KDM4EHSD17B10ALOX5APFEN1
SCHEMBL15426279 0.86 BRD4 (0.40) BRD4AKT1KDM4EAKT2ALOX5AP
SCHEMBL15412355 0.83 AKT1 (0.39) BRD4AKT1KDM4EHSD17B10AKT2
SCHEMBL15426287 0.81 AKT1 (0.37) BRD4AKT1KDM4EHSD17B10AKT2
SCHEMBL15426291 0.79 AKT1 (0.36) BRD4AKT1AKT2ALOX5APFEN1
SCHEMBL15426300 0.79 BRD4 (0.40) BRD4AKT1KDM4EHSD17B10AKT2
SCHEMBL15412648 0.78 POLB (0.43) AKT1ALOX5APFEN1ALDH1A1HPGD
SCHEMBL15412000 0.76 POLB (0.41) KDM4EHSD17B10ALOX5APFEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 BRD4 1677/4885AKT1 1919/4885KDM4E 2981/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 BRD4 1616/4885AKT1 1808/4885KDM4E 2968/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.