SCHEMBL15426388

SCHEMBL15426388

CCSc1cc(Cl)ccc1-c1nc2cc(C)cnc2n1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 1/20 0.37
BRD4 O60885 2/20 0.35
PDE2A O00408 1/20 0.35
PDE10A Q9Y233 1/20 0.35
HSD11B1 P28845 2/20 0.34
KDM4E B2RXH2 3/20 0.33
ALDH1A1 P00352 3/20 0.33
AKT1 P31749 2/20 0.33
AKT2 P31751 2/20 0.33
HPGD P15428 2/20 0.33
TSHR P16473 1/20 0.33
CYP1A2 P05177 1/20 0.33
F2RL3 Q96RI0 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
NPSR1 Q6W5P4 2/20 0.32
NR1I2 O75469 1/20 0.32
KMT2A Q03164 2/20 0.32
DDR1 Q08345 1/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426382 0.87 CYP11B1 (0.34) BRD4PDE10AALDH1A1AKT1AKT2
SCHEMBL15426452 0.87 AKT1 (0.33) BRD4PDE2APDE10AALDH1A1AKT1
SCHEMBL10280699 0.85 POLB (0.48) TNKSPDE2AHSD11B1ALDH1A1CYP1A2
SCHEMBL15412355 0.85 AKT1 (0.39) BRD4PDE10AHSD11B1KDM4EALDH1A1
SCHEMBL15426459 0.84 AKT1 (0.31) BRD4AKT1AKT2
SCHEMBL15426411 0.84 POLB (0.41) BRD4PDE10AHSD11B1AKT1AKT2
SCHEMBL20708856 0.84 POLB (0.36) TNKSHSD11B1TSHR
SCHEMBL10248971 0.83 PDE10A (0.36) BRD4PDE2APDE10AKDM4EALDH1A1
SCHEMBL18327921 0.83 BRD4 (0.36) BRD4PDE2APDE10AHPGDSMN1; SMN2
SCHEMBL16746511 0.82 POLB (0.36) PDE2APDE10ACYP1A2DDR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 TNKS 4731/4885BRD4 1677/4885PDE2A 3467/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 TNKS 4726/4885BRD4 1616/4885PDE2A 3420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.