Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.34 |
| ▸ | SHBG | P04278 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.33 |
| ▸ | SNCA | P37840 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.33 |
| ▸ | PGR | P06401 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857338 | 0.74 | POLB (0.37) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL6432193 | 0.73 | POLB (0.36) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL4274327 | 0.72 | POLB (0.37) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL7620452 | 0.71 | POLB (0.39) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL4273011 | 0.71 | CYP17A1 (0.39) | LMNAALDH1A1CYP3A4POLBCYP19A1 | |
| SCHEMBL4271500 | 0.70 | POLB (0.35) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL4276424 | 0.70 | POLB (0.38) | ESR2POLBCYP19A1 | |
| SCHEMBL4281037 | 0.70 | POLB (0.48) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL4281049 | 0.70 | POLB (0.35) | LMNAALDH1A1CYP3A4ESR2ESR1 | |
| SCHEMBL4279283 | 0.70 | POLB (0.35) | LMNAALDH1A1CYP3A4ESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684861-A2 | Spiro compounds and pharmaceutical use thereof | Japan Tobacco Inc. (JP) | 2014-01-15 | — | — | EP | disclosed |