SCHEMBL15427240

SCHEMBL15427240

CCSc1c(Cl)cccc1C(=O)Nc1cc(C(F)(F)F)cnc1NC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.44
MEN1 O00255 6/20 0.44
POLB P06746 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
MAPT P10636 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ALDH1A1 P00352 4/20 0.43
HPGD P15428 2/20 0.43
KDM4E B2RXH2 2/20 0.43
SORT1 Q99523 1/20 0.43
LMNA P02545 1/20 0.42
RXFP1 Q9HBX9 2/20 0.42
TP53 P04637 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
P2RX1 P51575 1/20 0.42
P2RX4 Q99571 1/20 0.42
P2RX7 Q99572 1/20 0.42
TMPRSS4 Q9NRS4 1/20 0.42
GAA P10253 1/20 0.42
TRPV1 Q8NER1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9952288 0.84 RXFP1 (0.48) KMT2AMEN1POLBMAPTALDH1A1
SCHEMBL16804795 0.82 KMT2A (0.43) KMT2AMEN1POLBSMN1; SMN2NPSR1
SCHEMBL22001425 0.80 KMT2A (0.44) KMT2AMEN1POLBSMN1; SMN2ALDH1A1
SCHEMBL20424031 0.80 TRPV1 (0.40) KMT2ASORT1P2RX1TRPV1
SCHEMBL17832717 0.80 KDM4E (0.40) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL20632268 0.79 KMT2A (0.41) KMT2AMEN1POLBSMN1; SMN2ALDH1A1
SCHEMBL16804777 0.78 HSD17B10 (0.42) KMT2AMEN1POLBALDH1A1SORT1
SCHEMBL16804775 0.78 GAA (0.44) KMT2AMEN1POLBALDH1A1SORT1
SCHEMBL16804792 0.77 KMT2A (0.38) KMT2AMEN1POLBSMN1; SMN2NPSR1
SCHEMBL16804767 0.77 KMT2A (0.38) KMT2AMEN1POLBSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006429-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2019-02-06 EP disclosed
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 KMT2A 700/4885MEN1 767/4885POLB 4715/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 KMT2A 675/4885MEN1 795/4885POLB 4737/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.