Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | FECH | P22830 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10325557 | 0.94 | MAP2K1 (0.40) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL12237872 | 0.94 | MAP2K1 (0.40) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL4081822 | 0.92 | MAP2K1 (0.48) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL26907228 | 0.92 | MAP2K1 (0.48) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL10326049 | 0.92 | MAP2K1 (0.48) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL10293630 | 0.91 | MAP2K1 (0.40) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL10325117 | 0.91 | MAP2K1 (0.40) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL14353091 | 0.89 | MAP2K1 (0.51) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL10293633 | 0.89 | MAP2K1 (0.51) | MAP2K1CDC7PLK4AURKARPS6KA4 | |
| SCHEMBL14353092 | 0.89 | MAP2K1 (0.51) | MAP2K1CDC7PLK4AURKARPS6KA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014009319-A1 | INDOLINONE DERIVATIVES ANTICANCER COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-16 | — | — | WO | disclosed |