Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | EPHB3 | P54753 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428710 | 0.91 | IRAK4 (0.46) | NPC1RAB9ASMN1; SMN2NLRP3JAK2 | |
| SCHEMBL15428576 | 0.89 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2JAK2IRAK4 | |
| SCHEMBL15428730 | 0.87 | TYK2 (0.47) | NPC1RAB9ASMN1; SMN2NLRP3JAK2 | |
| SCHEMBL15428752 | 0.86 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2NLRP3JAK2 | |
| SCHEMBL15428725 | 0.85 | EPHB3 (0.48) | NPC1RAB9ASMN1; SMN2NLRP3JAK2 | |
| SCHEMBL15428622 | 0.84 | TYK2 (0.46) | NPC1RAB9ASMN1; SMN2NLRP3JAK2 | |
| SCHEMBL15428663 | 0.83 | JAK2 (0.46) | NPC1RAB9ASMN1; SMN2JAK2IRAK4 | |
| SCHEMBL15428580 | 0.83 | EPHB3 (0.49) | NPC1RAB9ASMN1; SMN2NLRP3JAK2 | |
| SCHEMBL15428687 | 0.82 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2JAK2IRAK4 | |
| SCHEMBL15428727 | 0.82 | EPHB3 (0.47) | NPC1RAB9ASMN1; SMN2JAK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637526-B2 | Pyrazolopyrimidine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |