Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 13/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 13/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | LYN | P07948 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342943 | 0.91 | CDK1 (0.39) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL342942 | 0.91 | CDK1 (0.39) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL15428699 | 0.88 | CDK1 (0.41) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL342956 | 0.88 | CDK1 (0.39) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL15428718 | 0.87 | CDK2 (0.47) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL344726 | 0.87 | CDK1 (0.42) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL343043 | 0.87 | MERTK (0.42) | CDK1CDK2AURKAJAK2TYK2 | |
| SCHEMBL343868 | 0.87 | CDK1 (0.41) | CDK1CDK2CDK9AURKAJAK2 | |
| SCHEMBL343044 | 0.87 | MERTK (0.42) | CDK1CDK2AURKAJAK2TYK2 | |
| SCHEMBL10167396 | 0.87 | CDK1 (0.41) | CDK1CDK2CDK9AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |