Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 10/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428578 | 0.88 | NTRK1 (0.45) | EPHB3JAK2NTRK1LMNA | |
| SCHEMBL15428669 | 0.81 | NTRK1 (0.54) | JAK2NTRK1 | |
| SCHEMBL15428595 | 0.80 | SYK (0.45) | JAK2NTRK1LMNAIRAK4KDM4E | |
| SCHEMBL15428580 | 0.80 | EPHB3 (0.49) | EPHB3RIPK2LCKJAK2IRAK4 | |
| SCHEMBL15428575 | 0.79 | NTRK1 (0.43) | JAK2NTRK1LMNA | |
| SCHEMBL15428725 | 0.77 | EPHB3 (0.48) | EPHB3RIPK2LCKJAK2IRAK4 | |
| SCHEMBL15428663 | 0.76 | JAK2 (0.46) | EPHB3JAK2LMNAIRAK4KDM4E | |
| SCHEMBL15428727 | 0.74 | EPHB3 (0.47) | EPHB3JAK2NTRK1LMNAIRAK4 | |
| SCHEMBL15428620 | 0.74 | JAK2 (0.41) | JAK2NTRK1LMNAKDM4EPKM | |
| SCHEMBL405588 | 0.73 | IRAK4 (0.45) | EPHB3JAK2NTRK1LMNAIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637526-B2 | Pyrazolopyrimidine JAK inhibitor compounds and methods | GENENTECH, INC. (US) | 2014-01-28 | — | — | US | disclosed |