Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428827 | 0.84 | PTGDR2 (0.56) | PTGDR2CYP2C9PTGDRDRD2CYP3A4 | |
| SCHEMBL15428824 | 0.83 | PTGDR2 (0.55) | PTGDR2CYP2C9PTGDRDRD2DRD3 | |
| SCHEMBL2188133 | 0.80 | KCNA3 (0.41) | PTGDR2CYP2C9PTGDRKCNA3KMT2A | |
| SCHEMBL2190719 | 0.80 | PTGDR2 (0.61) | PTGDR2CYP2C9PTGDRCYP3A4 | |
| SCHEMBL15428825 | 0.77 | PTGDR2 (0.56) | PTGDR2CYP2C9PTGDRDRD2DRD3 | |
| SCHEMBL7661334 | 0.76 | KMT2A (0.44) | KCNA3KMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL15428831 | 0.75 | PTGDR2 (0.57) | PTGDR2PTGDRTBXA2R | |
| SCHEMBL2188345 | 0.72 | PTGDR2 (0.62) | PTGDR2CYP2C9PTGDRCCR5CYP3A4 | |
| SCHEMBL2187809 | 0.72 | PTGDR2 (0.59) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R | |
| SCHEMBL2188324 | 0.72 | PTGDR2 (0.59) | PTGDR2CYP2C9PTGDRCYP3A4TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346865-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK CANADA INC (CA) | 2015-07-15 | — | — | EP | disclosed |
| US-8637671-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK CANADA INC. (CA) | 2014-01-28 | — | — | US | disclosed |