Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 20/20 | 1.00 |
| ▸ | PTGDR | Q13258 | 17/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 13/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233949 | 1.00 | PTGDR2 (1.00) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL3242718 | 1.00 | PTGDR2 (1.00) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL232732 | 0.89 | PTGDR2 (0.80) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL3547689 | 0.85 | PTGDR2 (0.73) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL233258 | 0.85 | PTGDR2 (1.00) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL2190068 | 0.84 | PTGDR2 (0.72) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL2187459 | 0.83 | PTGDR2 (0.71) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL2188061 | 0.83 | PTGDR2 (0.71) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL3550194 | 0.83 | PTGDR2 (0.71) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R | |
| SCHEMBL2190260 | 0.83 | PTGDR2 (0.71) | PTGDR2PTGDRCYP2C9CYP3A4TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346865-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK CANADA INC (CA) | 2015-07-15 | — | — | EP | disclosed |
| US-8637671-B2 | Indole derivatives as CRTH2 receptor antagonists | MERCK CANADA INC. (CA) | 2014-01-28 | — | — | US | disclosed |