Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042494 | 0.84 | HDAC4 (0.62) | HDAC4CHRM3APOBEC3AAPOBEC3GHTT | |
| SCHEMBL1038755 | 0.84 | HDAC4 (0.62) | HDAC4CHRM3APOBEC3AAPOBEC3GHTT | |
| SCHEMBL1042365 | 0.84 | HDAC4 (0.62) | HDAC4CHRM3APOBEC3AAPOBEC3GHTT | |
| SCHEMBL1041983 | 0.82 | AKR1C1 (0.63) | HDAC4CHRM3APOBEC3AAPOBEC3GHTT | |
| SCHEMBL23164194 | 0.80 | NPC1 (0.52) | SMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL29262953 | 0.80 | HRH3 (0.53) | HDAC4HRH3APOBEC3AAPOBEC3GHTT | |
| SCHEMBL2481767 | 0.79 | AKR1C1 (0.58) | HDAC4CHRM3APOBEC3AAPOBEC3GHTT | |
| SCHEMBL1407574 | 0.79 | HRH3 (0.52) | HDAC4HRH3APOBEC3AAPOBEC3GL3MBTL1 | |
| SCHEMBL3486826 | 0.77 | CHRM3 (0.47) | HDAC4HRH3CHRM3APOBEC3AAPOBEC3G | |
| SCHEMBL3485510 | 0.76 | MAPT (0.53) | HDAC4HRH3CHRM3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307377-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Limited (GB) | 2011-04-13 | — | — | EP | disclosed |
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
| WO-2009153720-A1 | NICOTINAMIDE DERIVATIVES | PFIZER LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HDAC4 260/4885HRH3 166/4885ERCC1 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.