Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 3/20 | 0.58 |
| ▸ | AKT1 | P31749 | 2/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543935 | 0.84 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543838 | 0.83 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1543410 | 0.81 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL17833772 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL731496 | 0.78 | PIK3CA (0.80) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL1543811 | 0.78 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1619906 | 0.77 | AKT1 (0.82) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL730061 | 0.77 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL20099777 | 0.77 | PIK3C3 (0.73) | PIK3CAPIK3CDPIK3CGMTORAKT1 | |
| SCHEMBL732310 | 0.76 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |