Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.45 |
| ▸ | PPARA | Q07869 | 6/20 | 0.45 |
| ▸ | PPARD | Q03181 | 4/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 2/20 | 0.42 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.42 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.42 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.42 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.42 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15434180 | 1.00 | NPSR1 (0.47) | NPSR1SERPINE1PPARGPPARAPPARD | |
| SCHEMBL15434157 | 0.92 | NPSR1 (0.51) | NPSR1PPARGPPARAPPARDFFAR1 | |
| SCHEMBL15434106 | 0.92 | FFAR1 (0.48) | PPARGPPARAPPARDFFAR1FFAR4 | |
| SCHEMBL15434130 | 0.92 | FFAR1 (0.51) | NPSR1SERPINE1PPARGPPARAPPARD | |
| SCHEMBL2536068 | 0.91 | FFAR1 (0.46) | NPSR1SERPINE1PPARGPPARAPPARD | |
| SCHEMBL15434102 | 0.91 | FFAR1 (0.50) | SERPINE1PPARGPPARAPPARDFFAR1 | |
| SCHEMBL15434117 | 0.91 | NPSR1 (0.49) | NPSR1PPARGPPARAPPARDFFAR1 | |
| SCHEMBL15434118 | 0.91 | PPARD (0.46) | PPARGPPARAPPARDFFAR1FFAR4 | |
| SCHEMBL15434105 | 0.91 | PPARG (0.43) | NPSR1SERPINE1PPARGPPARAPPARD | |
| SCHEMBL15434113 | 0.90 | PPARG (0.44) | NPSR1SERPINE1PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633245-B2 | PAI-1 inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2014-01-21 | — | — | US | disclosed |