Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15425438 | 0.98 | ELANE (0.42) | ELANEKDM4EKMT2AMEN1CYP17A1 | |
| Formic Acid SCHEMBL15412289 | 0.94 | ELANE (0.41) | ELANEKDM4EKMT2AMEN1MAT2A | |
| Formic Acid SCHEMBL15412290 | 0.94 | ELANE (0.42) | ELANEKDM4EKMT2AMEN1CTSK | |
| SCHEMBL15412144 | 0.93 | ELANE (0.40) | ELANEAR | |
| SCHEMBL15412141 | 0.93 | ELANE (0.39) | ELANEAR | |
| SCHEMBL15411823 | 0.92 | ELANE (0.44) | ELANEKDM4EKMT2AMEN1CYP17A1 | |
| SCHEMBL15411066 | 0.92 | ELANE (0.44) | ELANEKDM4EKMT2AMEN1CYP17A1 | |
| SCHEMBL15410978 | 0.91 | ELANE (0.42) | ELANEKDM4EKMT2AMEN1CYP17A1 | |
| SCHEMBL15411663 | 0.91 | ELANE (0.42) | ELANEKDM4EKMT2AMEN1CYP17A1 | |
| SCHEMBL15412596 | 0.91 | ELANE (0.45) | ELANEKDM4EKMT2AMEN1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872509-B1 | INHIBITION OF ENZYMES | CHIESI FARMA SPA (IT) | 2016-09-14 | — | — | EP | claimed |
| EP-2872509-B1 | INHIBITION OF ENZYMES | CHIESI FARMA SPA (IT) | 2016-09-14 | — | — | EP | disclosed |
| WO-2014009425-A1 | INHIBITION OF ENZYMES | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-01-16 | — | — | WO | disclosed |