Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 5/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175016 | 0.80 | AURKA (0.69) | AURKAAURKB | |
| SCHEMBL10224892 | 0.76 | AURKA (0.38) | AURKAAURKBKDM4EMAPTESR1 | |
| SCHEMBL255869 | 0.74 | AURKA (0.37) | AURKAAURKBKDM4EMAPTESR1 | |
| SCHEMBL174414 | 0.72 | AURKA (0.73) | AURKAAURKB | |
| SCHEMBL164593 | 0.70 | GRM2 (0.47) | AURKAKDM4EESR1MEN1KMT2A | |
| SCHEMBL173218 | 0.70 | AURKA (0.76) | AURKAAURKB | |
| SCHEMBL174779 | 0.69 | AURKA (0.68) | AURKAAURKB | |
| SCHEMBL174492 | 0.68 | AURKA (0.78) | AURKAAURKBNQO2 | |
| SCHEMBL255856 | 0.68 | AURKA (0.66) | AURKAAURKB | |
| SCHEMBL174917 | 0.67 | AURKA (0.61) | AURKAAURKBKDM4EMAPTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401267-B1 | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND THEIR USE IN METHODS | AMBIT BIOSCIENCES CORP (US) | 2014-01-15 | — | — | EP | disclosed |