Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | GRK6 | P43250 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187346 | 0.87 | JAK2 (0.53) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL255861 | 0.87 | JAK2 (0.53) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL174658 | 0.87 | JAK2 (0.53) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL10224867 | 0.86 | JAK2 (0.69) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL15434543 | 0.86 | JAK2 (0.54) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL187194 | 0.86 | JAK2 (0.69) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL187195 | 0.86 | JAK2 (0.69) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL174606 | 0.86 | JAK2 (0.69) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL174255 | 0.75 | JAK2 (0.57) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL174254 | 0.75 | JAK2 (0.57) | JAK2CYP3A4CYP2C8CYP2C9JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401267-B1 | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND THEIR USE IN METHODS | AMBIT BIOSCIENCES CORP (US) | 2014-01-15 | — | — | EP | disclosed |