Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 4/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543469 | 0.88 | PIK3CA (0.63) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543227 | 0.78 | PIK3CA (0.72) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543438 | 0.78 | PIK3CA (0.51) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543738 | 0.77 | PIK3CA (0.57) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543536 | 0.75 | PIK3CA (0.75) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543367 | 0.74 | PIK3CA (0.60) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543256 | 0.74 | PIK3CA (0.62) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543785 | 0.73 | PIK3CA (0.57) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543591 | 0.73 | PIK3CA (0.57) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1543741 | 0.73 | PIK3CA (0.53) | PIK3CAPIK3CGPIK3CDMTORPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |