Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | STAT6 | P42226 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799547 | 1.00 | TUBB1 (0.55) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL58942 | 1.00 | TUBB1 (0.55) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL14568135 | 1.00 | TUBB1 (0.55) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL6805243 | 0.92 | TUBB1 (0.55) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL13848319 | 0.90 | TUBB1 (0.68) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL15434886 | 0.90 | TUBB1 (0.68) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL6806074 | 0.90 | TUBB1 (0.68) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL58351 | 0.90 | TUBB1 (0.68) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL13682076 | 0.89 | TUBB1 (0.67) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL57410 | 0.89 | TUBB1 (0.67) | TUBB1CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633224-B2 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | EISAI CO., LTD. (JP) | 2014-01-21 | — | — | US | disclosed |