Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL955289 | 0.80 | KMT2A (0.42) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL955291 | 0.80 | KMT2A (0.42) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL955290 | 0.80 | KMT2A (0.42) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL28276851 | 0.79 | KMT2A (0.44) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL1124416 | 0.78 | KMT2A (0.53) | KMT2ARAB9ASMN1; SMN2NPC1CDK5 | |
| SCHEMBL1124418 | 0.78 | KMT2A (0.53) | KMT2ARAB9ASMN1; SMN2NPC1CDK5 | |
| SCHEMBL472513 | 0.78 | KMT2A (0.47) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL265343 | 0.78 | KMT2A (0.43) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL1311750 | 0.78 | KMT2A (0.43) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL16860885 | 0.77 | KMT2A (0.43) | KMT2ARAB9ASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687507-B1 | NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND | TAISHO PHARMACEUTICAL CO LTD (JP) | 2016-03-09 | — | — | EP | disclosed |
| US-9035059-B2 | Nitrogen-containing condensed heterocyclic compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-05-19 | — | — | US | disclosed |
| US-9035059-B2 | Nitrogen-containing condensed heterocyclic compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2015-05-19 | — | — | US | disclosed |
| EP-2687507-A1 | NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-01-22 | — | — | EP | disclosed |