Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 13/20 | 0.51 |
| ▸ | RAF1 | P04049 | 12/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374342 | 0.89 | RAF1 (0.56) | LCKMAPK14BRAFRAF1CSF1R | |
| SCHEMBL374105 | 0.88 | LCK (0.55) | LCKMAPK14BRAFRAF1CSF1R | |
| SCHEMBL374565 | 0.85 | LCK (0.54) | LCKMAPK14BRAFRAF1CSF1R | |
| SCHEMBL374560 | 0.84 | LCK (0.56) | LCKMAPK14BRAFRAF1CSF1R | |
| SCHEMBL374318 | 0.81 | CSF1R (0.54) | LCKBRAFRAF1CSF1RKIT | |
| SCHEMBL374295 | 0.81 | LCK (0.53) | LCKMAPK14BRAFRAF1CSF1R | |
| SCHEMBL374320 | 0.80 | LCK (0.53) | LCKMAPK14BRAFRAF1EPHX2 | |
| SCHEMBL374431 | 0.77 | LCK (0.60) | LCKMAPK14BRAFCSF1R | |
| SCHEMBL374676 | 0.76 | LCK (0.61) | LCKMAPK14BRAFRAF1 | |
| SCHEMBL374344 | 0.75 | BRAF (0.56) | LCKBRAFRAF1CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418205-B1 | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG (CH) | 2014-01-22 | — | — | EP | disclosed |