Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.66 |
| ▸ | FLT3 | P36888 | 4/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.66 |
| ▸ | BCR | P11274 | 1/20 | 0.66 |
| ▸ | FRK | P42685 | 1/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.66 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.66 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.66 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.66 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.66 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.66 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.66 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.66 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276539 | 0.95 | RET (0.72) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL10290519 | 0.91 | FGFR1 (0.64) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL276659 | 0.90 | RET (0.72) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL275883 | 0.89 | FGFR1 (0.76) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL275119 | 0.89 | FGFR1 (0.84) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL276505 | 0.87 | RET (0.69) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL276617 | 0.87 | RET (0.68) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL275502 | 0.86 | RET (0.67) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL275488 | 0.85 | RET (0.66) | RETFLT3FGFR1BCRFRK | |
| SCHEMBL276147 | 0.85 | FLT3 (0.58) | RETFLT3FGFR1BCRFRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957077-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2014-01-22 | — | — | EP | disclosed |