SCHEMBL15436010

SCHEMBL15436010

O=C(c1ccc([N+](=O)[O-])cc1)c1cnc(N[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)s1

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.44
ADK P55263 1/20 0.44
LGALS3 P17931 1/20 0.43
GRK6 P43250 2/20 0.42
CA1 P00915 9/20 0.39
CA2 P00918 9/20 0.39
CA9 Q16790 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15436011 1.00 TSHR (0.44) TSHRADKLGALS3GRK6CA1
SCHEMBL16946211 1.00 TSHR (0.44) TSHRADKLGALS3GRK6CA1
SCHEMBL16941671 1.00 TSHR (0.44) TSHRADKLGALS3GRK6CA1
SCHEMBL15445169 1.00 TSHR (0.44) TSHRADKLGALS3GRK6CA1
SCHEMBL15436009 0.86 TSHR (0.50) TSHRGRK6CA1CA2CA9
SCHEMBL15436008 0.86 TSHR (0.50) TSHRGRK6CA1CA2CA9
SCHEMBL15445173 0.86 TSHR (0.50) TSHRGRK6CA1CA2CA9
SCHEMBL15436093 0.86 SMN1; SMN2 (0.53) TSHRCA1CA2CA9
SCHEMBL16946203 0.86 TSHR (0.50) TSHRGRK6CA1CA2CA9
SCHEMBL15436094 0.86 SMN1; SMN2 (0.53) TSHRCA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2900678-B1 MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG CENTRE NAT RECH SCIENT (FR) 2020-09-02 EP disclosed
US-10273313-B2 Multimeric mannosides, a process for preparing the same and their uses as a drug CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-30 US disclosed
EP-2900678-A1 MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG Centre National de la Recherche Scientifique (C.N.R.S.) (FR) 2015-08-05 EP disclosed
US-20150210781-A1 MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG NANTES UNIVERSITE (FR) 2015-07-30 US disclosed
WO-2014016361-A1 MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2014-01-30 WO disclosed
EP-2690105-A1 Mannose derivatives, a process for preparing the same and their uses as a drug Centre National De La Recherche Scientifique (FR) 2014-01-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10273313-B2 Multimeric mannosides, a process for preparing the same and their uses as a drug MANBA, MAN2A1, MAN2B2 TSHR 4747/4885ADK 1279/4885LGALS3 114/4885
US-20150210781-A1 MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG MANBA, MAN2A1, MAN2B2 TSHR 4747/4885ADK 1279/4885LGALS3 114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.