Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 15/20 | 0.42 |
| ▸ | KDR | P35968 | 10/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10316679 | 0.86 | AXL (0.55) | AXLKDRKDM4E | |
| SCHEMBL1640465 | 0.86 | AXL (0.55) | AXLKDRKDM4E | |
| SCHEMBL10317023 | 0.78 | AXL (0.52) | AXLKDRKDM4E | |
| SCHEMBL15754378 | 0.77 | AXL (0.53) | AXLKDR | |
| SCHEMBL18009411 | 0.77 | AXL (0.40) | AXLKDRKDM4E | |
| SCHEMBL28861630 | 0.76 | KIT (0.48) | AXLKDR | |
| SCHEMBL15759220 | 0.73 | SLC18A3 (0.56) | SLC18A3KDM4E | |
| SCHEMBL13468233 | 0.73 | SLC18A3 (0.58) | SLC18A3KDM4E | |
| SCHEMBL30276317 | 0.72 | TLR9 (0.38) | SLC18A3 | |
| SCHEMBL10264029 | 0.70 | SLC18A3 (0.40) | SLC18A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078010-B1 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2014-01-29 | — | — | EP | disclosed |