Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365720 | 0.90 | JAK2 (0.52) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL1365716 | 0.90 | JAK2 (0.52) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL1368051 | 0.89 | JAK2 (0.48) | JAK2JAK3JAK1TYK2NTRK1 | |
| SCHEMBL1368012 | 0.88 | JAK2 (0.55) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL1368007 | 0.88 | JAK2 (0.55) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL1368609 | 0.88 | JAK2 (0.51) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL1368605 | 0.88 | JAK2 (0.51) | JAK2JAK3JAK1TYK2KCNH2 | |
| Hydrochloric Acid SCHEMBL1368475 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1TYK2KCNH2 | |
| Hydrochloric Acid SCHEMBL1368478 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1TYK2KCNH2 | |
| Hydrochloric Acid SCHEMBL1368927 | 0.87 | JAK2 (0.51) | JAK2JAK3JAK1TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394999-B1 | AMINOPYRAZINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO LTD (JP) | 2014-01-29 | — | — | EP | claimed |