Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 14/20 | 0.59 |
| ▸ | KIT | P10721 | 4/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189779 | 0.79 | CSF1R (0.67) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL14383327 | 0.77 | CSF1R (0.71) | CSF1RKIT | |
| SCHEMBL14383523 | 0.75 | CSF1R (0.71) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL14383324 | 0.75 | CSF1R (0.77) | CSF1RKIT | |
| SCHEMBL14383515 | 0.75 | CSF1R (0.78) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL14383520 | 0.74 | CSF1R (1.00) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL14383332 | 0.73 | CSF1R (0.75) | CSF1RKIT | |
| SCHEMBL14383517 | 0.73 | CSF1R (1.00) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL14405109 | 0.73 | CSF1R (0.67) | CSF1RKITNTRK1LCKCYP3A4 | |
| SCHEMBL14383321 | 0.73 | CSF1R (0.74) | CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687516-A1 | Inhibitors of C-FMS Kinase | Janssen Pharmaceutica N.V. (BE) | 2014-01-22 | — | — | EP | disclosed |