Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 20/20 | 0.55 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436295 | 1.00 | PTGDR2 (0.55) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL14765390 | 0.84 | PTGDR2 (0.42) | PTGDR2PTGDRTBXA2R | |
| SCHEMBL15436635 | 0.79 | PTGDR2 (0.45) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL12355547 | 0.79 | PTGDR2 (0.64) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL15428822 | 0.79 | PTGDR2 (0.61) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL15428826 | 0.76 | PTGDR2 (0.65) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL3663654 | 0.76 | PTGDR2 (0.65) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL15428823 | 0.74 | PTGDR2 (0.63) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 | |
| SCHEMBL2186855 | 0.72 | PTGDR2 (0.92) | PTGDR2PTGDR | |
| SCHEMBL15436634 | 0.72 | PTGDR2 (0.52) | PTGDR2PTGDRTBXA2RCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401269-B1 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-29 | — | — | EP | disclosed |