Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.78 |
| ▸ | MTOR | P42345 | 5/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.63 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.63 |
| ▸ | PRKDC | P78527 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543986 | 0.87 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543968 | 0.85 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543572 | 0.83 | PIK3CA (0.75) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543935 | 0.81 | PIK3CA (0.77) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1544074 | 0.81 | PIK3CA (0.79) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543931 | 0.80 | PIK3CA (0.75) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543576 | 0.79 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543447 | 0.77 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543787 | 0.77 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1544522 | 0.77 | PIK3CA (0.73) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | claimed |
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |