Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.92 |
| ▸ | MTOR | P42345 | 4/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.72 |
| ▸ | PRKDC | P78527 | 1/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543681 | 0.96 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1544003 | 0.88 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543892 | 0.86 | PIK3CA (0.81) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543730 | 0.85 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543375 | 0.85 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543967 | 0.84 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543779 | 0.83 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543512 | 0.83 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1543942 | 0.83 | PIK3CA (0.78) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL24522277 | 0.81 | PIK3CA (0.77) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | claimed |
| EP-2307400-A2 | INHIBITORS OF PI3 KINASE | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009155121-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |