Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 17/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.61 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48678 | 0.85 | PI4KB (0.69) | PI4KBPIK3CDPIK3CGPIK3CA | |
| SCHEMBL48423 | 0.84 | PI4KB (0.68) | PI4KBPIK3CDPIK3CGPIK3CA | |
| SCHEMBL48791 | 0.84 | PI4KB (0.68) | PI4KBPIK3CDPIK3CGPIK3CA | |
| SCHEMBL6550793 | 0.80 | PI4KB (0.58) | PI4KBPIK3CDPIK3CGPIK3C2GPIK3CA | |
| SCHEMBL49055 | 0.80 | PIK3CD (0.66) | PI4KBPIK3CDPIK3CGPIK3CA | |
| SCHEMBL48581 | 0.80 | PIK3CD (0.76) | PI4KBPIK3CDPIK3CGPIK3C2GPIK3CA | |
| SCHEMBL48488 | 0.80 | PIK3CD (0.73) | PI4KBPIK3CDPIK3CGPIK3C2GPIK3CA | |
| SCHEMBL48498 | 0.79 | PIK3CD (0.72) | PI4KBPIK3CDPIK3CGPIK3C2GPIK3CA | |
| SCHEMBL48630 | 0.79 | PIK3CD (0.72) | PI4KBPIK3CDPIK3CGPIK3C2GPIK3CA | |
| SCHEMBL1235131 | 0.78 | PIK3CG (0.43) | PI4KBPIK3CDPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480962-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-24 | — | — | EP | claimed |
| EP-2311818-B1 | Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug | NOVARTIS AG (CH) | 2013-01-16 | — | — | EP | disclosed |
| EP-1480962-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-08-24 | — | — | EP | disclosed |
| EP-2311818-A1 | Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug | Novartis AG (CH) | 2011-04-20 | — | — | EP | disclosed |
| US-7687637-B2 | 5-phenylthiazole derivatives and use as Pi3 kinase inhibitors | NOVARTIS AG (CH) | 2010-03-30 | — | — | US | disclosed |